SMARCAL1 deficiency predisposes to non-Hodgkin lymphoma and hypersensitivity to genotoxic agents in vivo
نویسندگان
چکیده
منابع مشابه
Hodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma
Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...
متن کاملNovel Targeted Agents in Hodgkin and Non-Hodgkin Lymphoma Therapy
There has been a recent emergence of novel targeted agents for treatment of Hodgkin and non-Hodgkin lymphoma. In particular, antibodies and antibody-drug conjugates directed against surface antigens, agents that block immune checkpoint pathways, and small molecule inhibitors directed against cell signaling pathways have shown significant promise in patients with relapsed and refractory disease ...
متن کاملNON-HODGKIN\'S LYMPHOMA IN IRAN
Two hundred and ninety cases of non-Hodgkin's lymphoma from the Fars Province Cancer Registry and Mashad University Hospital were reviewed and classified according to the new International Working Formulation for clinical use. The cases fall into low-grade (35 male, 26 female), intermediate-grade (61 male, 26 female), and high-grade (84 male, 26 female) groups. Each group includes several ...
متن کاملNon-Hodgkin Lymphoma (NHL) in Pakistan
Lymphomas are classified as Hodgkin’s and Non-Hodgkin’s lymphomas (HL NHL) NHL being further sub-divided into B, T and Null cell categories on the basis of WHO classification. With a few exceptions worldwide, B-NHL are more common, accounting approximately 80-85% of all cases of NHL compared to T-NHL, which accounts for about 10-15% of all NHL cases. The incidence of NHL has shown a steady incr...
متن کاملRunx1 deficiency predisposes mice to T-lymphoblastic lymphoma (Running title: Runx1 deficiency and lymphoma)
Genetics and Molecular Biology Branch, Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; Department of Biochemistry, Dartmouth Medical School, Hanover, NH; Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD. M.K. is a recipient of a Damon-Runyon Cancer Research Fund Fel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Medical Genetics Part A
سال: 2012
ISSN: 1552-4825
DOI: 10.1002/ajmg.a.35532